By Prosper Mene
recent study provides new insights into why chronic pain often lasts longer in women than in men, pointing to biological differences in the immune system rather than psychological factors.
The research which was published on February 20, 2026, in the journal Science Immunology, the research, titled “Monocyte-derived IL-10 drives sex differences in pain duration” was led by Geoffroy Laumet, an associate professor of physiology at Michigan State University, along with first author Jaewon Sim and colleagues.
The study reveals that a specific subset of immune cells called monocytes plays a key role in resolving pain by releasing an anti-inflammatory molecule known as IL-10 (interleukin-10). These IL-10-producing monocytes help “switch off” pain signals by communicating with sensory neurons. In males, these cells are more active, leading to faster pain resolution. This heightened activity is driven by higher levels of male sex hormones, particularly testosterone.
In contrast, females have less active IL-10-producing monocytes, resulting in delayed recovery and more persistent pain. The researchers observed this pattern consistently in mouse models of inflammatory painย and in human data from patients recovering from traumatic injuries, where men resolved pain more quickly and showed higher circulating levels of these monocytes and IL-10.
Experiments further confirmed the hormonal link: Blocking male sex hormones in mice reduced the activity of these pain-resolving monocytes, while treatments that boosted them (such as the lipid mediator resolvin D1) accelerated pain relief in both sexes.
For years, women have reported more frequent, severe, and prolonged chronic pain conditions, such as fibromyalgia, migraines, and musculoskeletal issues, yet their experiences were sometimes dismissed. This study validates those reports with evidence of a clear biological mechanism, shifting focus from pain initiation to why it persists.
The findings could pave the way for targeted, non-opioid therapies that enhance pain resolution, especially for women. As Laumet noted in related coverage, the difference lies in the immune system’s ability to shut down pain signals, not in perception alone.
This research bares the importance of considering sex differences in pain management and medical research to develop more equitable treatments.
